P5 eHealth: An Agenda for the Health Technologies of the Future -- Preface -- Contents -- About the Editors -- Part I: Foundations for P5 eHealth -- Chapter 1: A "P5" Approach to Healthcare and Health Technology -- 1 Introduction -- 2 P5 Medicine -- 3 eHealth -- 3.1 Strengths of eHealth -- 3.2 Criticalities of eHealth and Emerging Challenges -- 4 Conclusion -- References -- Chapter 2: The Development of iManageCancer: The Experience of a Personalised eHealth Platform for Cancer Patients' Empowerment -- 1 Introduction -- 2 The IManageCancer Platform -- 2.1 My HealthAvatar for iManageCancer -- 2.2 iManageMyHealth -- 2.3 iManageCancer Portal iPHR -- 2.4 Game for Adults -- 3 iManageCancer Within the p5 Approach -- 4 Conclusion -- References -- Part II: The 5 Ps and eHealth -- Chapter 3: The Prevention of Chronic Diseases Through eHealth: A Practical Overview -- 1 Introduction -- 2 Risk Factors for Chronic Diseases -- 3 Primary, Secondary, and Tertiary eHealth Prevention -- 4 Population-Based vs. Individual-Based eHealth Prevention -- 5 eHealth Behavioral Change Interventions -- 6 Strategies of eHealth Prevention -- 7 Conclusion -- References -- Chapter 4: An Introduction to Personalized eHealth -- 1 Introduction -- 1.1 What Are the News of Personalized Medicine? -- 1.2 A Brief History -- 2 The Development of Personalized Medicine -- 2.1 Treatments -- 2.2 Diagnosis and Risk Prediction -- 2.3 Doctor-Patient Communication -- 2.4 Disease/Illness Management -- 3 The Role of eHealth (and mHealth Specifically) -- 4 Liability: The Road Toward Becoming Active Patients -- 5 Communication Through eHealth -- 6 Health Social Networks -- 7 Challenges to eHealth Usages and Possible Solutions -- 8 Conclusion -- References -- Chapter 5: Predictive Precision Medicine: Towards the Computational Challenge -- 1 Introduction -- 2 Predictive Medicine and Precision Medicine.

3 Imaging Techniques, Artificial Intelligence and Machine Learning -- 3.1 Imaging Techniques -- 3.2 Artificial Intelligence and Machine Learning -- 3.3 Medical Imaging and Machine Learning -- 4 Predictive Precision Medicine in Neurodegenerative Diseases -- 4.1 Current Application: From Dementias to Parkinson's Disease -- 5 Conclusion -- References -- Chapter 6: Participatory Aspects of ICT Infrastructures for Cancer Management -- 1 Introduction -- 2 Participatory Aspects for Cancer Management -- 2.1 From Personalized to Participatory Medicine -- 2.2 Critical Factors of Participatory Medicine -- 2.3 Psychological Factors as Moderators of Participatory Medicine -- 3 ICT Solutions from Relevant EU Projects -- 3.1 iManageCancer -- 3.1.1 Technological Contribution -- 3.1.2 Participatory Aspect of the Developed Solution -- 3.1.3 Lessons Learnt -- 3.2 MyHealthAvatar -- 3.2.1 Technological Contribution -- 3.2.2 Participatory Aspect of the Developed Solution -- 3.2.3 Lessons Learnt -- 3.3 p-Medicine -- 3.3.1 Technological Contribution -- 3.3.2 Participatory Aspect of the Developed Solution -- 3.3.3 Lessons Learnt -- 3.4 EURECA -- 3.4.1 Technological Contribution -- 3.4.2 Participatory Aspects of the Developed Solution -- 3.4.3 Lessons Learnt -- 3.5 INTEGRATE -- 3.5.1 Technological Contribution -- 3.5.2 Participatory Aspect of the Developed Solution -- 3.5.3 Lessons Learnt -- 4 Conclusions and Guidelines for Future Development -- References -- Chapter 7: Psycho-cognitive Factors Orienting eHealth Development and Evaluation -- 1 The P5 and the Personomics Approach -- 2 The Key Elements for the P5-Personomics Approach -- 3 Solutions Come from the eHealth Apps -- 4 Digital Health in the Patient's Journey -- 4.1 A Possible Scenario -- 5 The Importance of Patient Education -- 6 Persuasive Design Technology -- 7 Conclusion -- References.

Part III: Important Aspects for P5 Technologies Development and Utilization -- Chapter 8: Role of Next-Generation Sequencing Technologies in Personalized Medicine -- 1 Historic Background of DNA Sequencing -- 1.1 The NGS Revolution in the Context of Precision Medicine -- 2 Technical Aspects: From Sanger Sequencing to NGS -- 2.1 Library Preparation and Amplification -- 2.2 Sequencing -- 2.3 Data Analysis -- 3 NGS Methods: Genomics, Transcriptomics, and Epigenomics -- 3.1 Genomics -- 3.2 Transcriptomics -- 3.3 Epigenomics -- 4 NGS Applications for a Personalized Oncology -- 4.1 Detection of Driver Alterations and Resistance -- 4.1.1 Lung Cancer -- 4.1.2 Breast Cancer -- 4.1.3 Carcinoma of Unknown Primary Site -- 4.2 Biomarkers -- 4.2.1 Homologous Recombination Deficiency -- 4.2.2 Microsatellite Instability -- 4.2.3 Tumor Mutational Burden -- 4.3 Liquid Biopsy -- 4.3.1 Early Diagnosis of Primary Disease -- 4.3.2 Early Detection of Relapse -- 4.3.3 Detection of Driver/Resistance Mutations and Real-Time Monitoring of Therapies -- 4.3.4 Characterization of Tumor Heterogeneity -- 4.3.5 CTCs and ctDNA Analysis -- 5 NGS Implementation in Clinical Practice: Challenges and Limitations -- References -- Chapter 9: User-Centered Design Approaches and Methods for P5 eHealth -- 1 Introduction -- 2 From Ergonomics to User-Centered Design -- 2.1 Interaction Factors -- 2.2 Motivation and Emotion -- 2.2.1 Motivation in Design -- 2.2.2 Emotion in Design -- 2.3 Context -- 2.3.1 Individual and Psychosocial Dimensions of Context -- 2.3.2 Cultural and Relational Dimensions of Context -- 2.3.3 Physical and Material Dimension of Context -- 3 User-Centered Design and P5 eHealth -- References -- Chapter 10: Data Protection and Ethical Issues in European P5 eHealth -- 1 Introduction -- 2 eHealth in the European Union: From Advancement of Innovation to Data Protection Concerns.

3 The GDPR and Its Impact on eHealth Research and Innovation -- 3.1 The Accountability Principle and its Implications -- 3.2 Pseudonymization and Anonymization of Sensitive Data -- 3.3 The "Right Balance" Between Innovation and Protection of Individuals' Rights and Interests? -- 4 Ethical Issues in eHealth Technologies -- 4.1 Online eHealth (Self-Management) Tools -- 4.2 Monitoring Techniques -- 4.3 New and Unconventional eHealth Technologies -- 5 Conclusions -- References.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2023. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.