Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Anatomy and Physiology of the Brain: Pathophysiology of Brain Tumor -- Amitha Muraleedharan1,* and Nikhil Ponnoor Anto1 -- INTRODUCTION -- THE ANATOMY OF THE HUMAN BRAIN -- Cerebrum -- Subcortical Structures -- The Diencephalon -- Brain Stem -- Cerebellum -- Circulation and CSF -- MICROANATOMY -- DEVELOPMENT -- PHYSIOLOGY -- Action Potential -- Graded Potential -- Synapse -- Physiological Anatomy of A Synapse -- BRAIN TUMOR (BT) -- Pathophysiology of BT -- Signs and Symptoms of BT -- Diagnosis Therapy -- Complications -- Investigative Therapies -- FUTURE DIRECTIONS -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- Barriers to Targeted Drug Delivery Strategies in Brain -- Payal Kesharwani1,2, Kajal Kumari1, Smita Jain1 and Swapnil Sharma1,* -- INTRODUCTION -- BRAIN TUMOUR: CAUSE, SYMPTOMS, CATEGORY, AND LIMITATIONS OF CONVENTIONAL THERAPY -- Brain Tumour: Cause and Symptoms -- Classification of Brain Tumour -- Limitations of Conventional Treatment -- DIFFERENT BARRIERS AND TRANSPORTATION PATHWAYS FOR THE DELIVERY OF DRUGS TO BRAIN TUMOURS -- Blood-Brain Barrier (BBB) -- Carrier Mediated BBB Transport (CMT) -- Absorptive Mediated Transcytosis (AMT) -- Receptor-Mediated Transcytosis (RMT) -- Blood-Brain-Tumor Barrier (BBTB) -- Tumour Microenvironment -- APPLICATION -- Vesicular Drug Delivery for Brain Tumour Theranostic -- Liposomal Nanoparticles for Brain Tumour Theranostic -- Exosomes for Brain Tumour Theranostic -- Niosomes for Brain Tumour Theranostic -- Nanoparticles for Brain Tumour Theranostic -- Polymeric Nanoparticles -- Inorganic-Nanoparticles for Brain Tumour Theranostic -- Stimuli-Responsive Strategies to Deliver a Drug at Tumour Site -- Non-Invasive Techniques: To Focus Ultrasound-Induced Brain Vascular Permeability Increment.

CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- Theranostics Polymeric Nanoparticles for Brain Tumor Diagnosis and Treatment -- Sivadas Swathi Krishna1, Ardra Thottarath Prasanthan1, Nirdesh Salim Kumar1, Manish Philip1 and Vidya Viswanad1,* -- INTRODUCTION -- MECHANISMS OF TARGETED DRUG DELIVERY IN BRAIN TUMOR -- The Blood-Brain Barrier Targeting Mechanism -- Absorptive Mediated Transcytosis -- Transporter Mediated Transcytosis -- Receptor-Mediated Transcytosis -- Blood-Brain Tumor Barrier Targeting Mechanism -- Enhanced Permeability And Retention (EPR) Effect-Based Strategies -- POLYMERIC NANOPARTICLES BASED DIAGNOSIS AND TREATMENT OF BRAIN TUMOR -- TYPES OF POLYMERIC NANOPARTICLES IN DRUG DELIVERY AND TREATMENT -- POLYMERIC NANOPARTICLES IN BRAIN TUMOR DIAGNOSIS -- THERANOSTICS -- THERANOSTICS IN BRAIN TUMOR MANAGEMENT -- APPLICATION OF VARIOUS POLYMERIC NANOPARTICLES AS THERANOSTICS IN BRAIN TUMOR -- Gold Nanoparticles -- Magnetic Nanoparticle -- Quantum Dots -- BRAIN TUMOR TREATMENT AND DIAGNOSIS- SOLUTIONS THROUGH NANO THERANOSTICS -- NANOPLATFORMS FOR BRAIN TUMOR IMAGING -- PERSONALIZED MEDICINE: A POSSIBLE SCENARIO IN THERANOSTICS -- POLYMER-BASED SUPERPARAMAGNETIC NANOPARTICLES AS THERANOSTICS FOR BRAIN TUMOR -- ULTRASOUND-TRIGGERED POLYMERIC NANOPARTICLES AS THERANOSTICS FOR BRAIN TUMOR -- POLYMERIC NANOPARTICLES BEARING RADIONUCLIDE AS THERANOSTICS FOR BRAIN TUMOR [6] -- FLUORESCENT POLYMERIC NANOPARTICLES AS THERANOSTICS FOR BRAIN TUMOR -- CHALLENGES AND FUTURE DIRECTIONS -- CONCLUSION -- RECOMMENDATIONS -- REFERENCES -- Theranostic Liposome for Brain Tumor Diagnosis and Treatment -- Payal Kesharwani1,2, Shiv Kumar Prajapati3, Devesh Kapoor4, Smita Jain1 and Swapnil Sharma1,* -- INTRODUCTION -- MECHANISM OF LIPOSOMES TARGETING BBB AND BBTB -- STRATEGIES TO TARGET BRAIN TUMOUR USING LIPOSOMES -- Protein Targets.

Small Molecules as Targets -- Dual Targeting Approach -- Gene Therapy-Based Targeting Liposome -- LIPOSOMES AS A CARRIER FOR IMAGING AGENT -- Fluorescence Imaging -- Magnetic Resonance Imaging [MRI] -- Ultrasound Imaging -- LIPOSOMES AS NANOCARRIERS FOR DIAGNOSTIC APPLICATIONS -- MAJOR CHALLENGES FACED DURING THE DEVELOPMENT OF LIGAND-GATED LIPOSOMES -- CONCLUSION AND FUTURE PROSPECTIVE -- LIST OF ABBREVIATION -- ACKNOWLEDGEMENT -- REFERENCES -- Theranostics Dendrimer for Brain Tumor Diagnosis and Treatment -- Theranostics Nanoemulsion for Brain Tumor Diagnosis and Treatment -- Deepak Prashar1,*, Ram Kumar Sahu2, Jiyauddin Khan3, Oluwadunsin Iyanuoluwa Adebayo4 and Grace Fumilayo Adigun4 -- INTRODUCTION -- BASICS OF NANOEMULSION -- Brain Tumor Nanoemulsion -- Advancements in Nanoemulsions For Tumor Diagnosis and Treatment -- FUTURE PERSPECTIVE -- CONCLUSION -- ACKNOWLEDGEMENTS -- REFERENCES -- Theranostics Micelles for Brain Tumor Diagnosis and Treatment -- Theranostics Inorganic Nano-particles for Brain Tumor Diagnosis and Treatment -- Krishna Yadav1, Swati Dubey2, Shalini Singh2, Geetika Sharma2, Madhulika Pradhan3, Narayana Subbiah Hari Narayana Moorthy2 and Sunita Minz2,* -- INTRODUCTION -- BARRIERS TO TARGETED DRUG DELIVERY STRATEGIES IN BLOOD BRAIN BARRIER -- Blood-Brain Barrier Targeting Methods and Related Mechanisms -- Receptor-Mediated Transcytosis (RMT) -- Adsorptive-Mediated Transcytosis (AMT) -- Transport Mediated Transcytosis (TMT) -- Blood-Brain Tumor Barrier (BBTB) Targeting Methods and Related Mechanism -- Angiogenesis-Specific Targeted Drug Delivery -- The BBTB's Negatively Charged Pores were Targeted for Drug Delivery -- Strategies based on the Enhanced Permeability and Retention Effect (EPR) Effect and Related Nano-Drug Delivery Systems -- INORGANIC NANO-PARTICLES (NPS) AS THERANOSTIC SYSTEMS AND THEIR APPLICATIONS.

Brain Tumor Imaging and Therapy Utilizing NPs -- Inorganic NPs for Diagnostic and Therapeutic Purposes -- Theranostic Potential of Inorganic NPs -- Preclinical Stages and Clinical Studies of Theranostic NPs -- CONCLUSION -- REFERENCES -- Subject Index -- Back Cover.

Brain Tumor Targeting Drug Delivery Systems: Advanced Nanoscience for Theranostics Applications is a comprehensive reference focused on the latest advancements in nanotechnology for brain tumor therapy. With practical insights and cutting-edge research, this book equips readers with the knowledge to develop innovative drug delivery systems for effective brain tumor diagnosis and treatment. Structured into insightful chapters, this book covers the anatomy, physiology, and pathophysiology of the brain, addressing barriers to targeted drug delivery strategies. Chapters explore theranostics-based delivery systems, including polymeric nanoparticles, liposomes, dendrimers, nanoemulsions, micelles, and inorganic nanoparticles, for precise brain tumor diagnosis and treatment. This informative resource is designed for students and research scholars in pharmacology, pharmaceutical industry scientists, professors, and clinical medicine researchers. With comprehensive chapters and references for further reading, this book facilitates easy understanding of the intricate nanomedical technology, empowering researchers to make significant strides in the field of brain tumor therapy. Key Features: Structured chapters for easy understanding of nanotechnology conceptsIn-depth coverage of theranostics-based delivery systems for brain tumor diagnosis and treatmentReferences for further reading and exploring new advances in drug delivery systems.

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Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, 2024. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries.